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Optimizing shared decision-making for risk-reducing mastectomy in women with Li–Fraumeni syndrome using patient-reported outcome measures

3 Jun 2025

Abstract excerpt

Decisions regarding risk-reducing mastectomy (RRM) in women with Li-Fraumeni Syndrome (LFS) are challenged by unclear survival benefits and potential quality of life (QOL) impacts. We evaluated QOL in LFS women and identified factors associated with QOL outcomes in those who received RRM. LFS women from a single institution cohort between 2012 and 2022 were identified and BREAST-Q surveys were administered....

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PMID: 40461682
DOI: 10.1038/s41598-025-89068-z

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