Article
Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.
Acta neuropathologica - 1 Jan 2018
Stone Thomas J, Keeley Angus, Virasami Alex, Harkness William, Tisdall Martin, Izquierdo Delgado Elisa, Gutteridge Alice, Brooks Tony, Kristiansen Mark, Chalker Jane, Wilkhu Lisa, Mifsud William, Apps John, Thom Maria, Hubank Mike, Forshew Tim, Cross J Helen, Hargrave Darren, Ham Jonathan, Jacques Thomas S
Abstract excerpt
Glioneuronal tumours are an important cause of treatment-resistant epilepsy. Subtypes of tumour are often poorly discriminated by histological features and may be difficult to diagnose due to a lack of robust diagnostic tools. This is illustrated by marked variability in the reported frequencies across different epilepsy surgical series. To address this, we used DNA methylation arrays and RNA sequencing to assay...
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