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Hyperoside exposure impairs cardiac development in zebrafish embryos: Evidence from phenotyping, transcriptomics, and antioxidant rescue.

Toxicology and applied pharmacology - 1 Aug 2026

Zhou ZhuoShuo, Yang Yilin, Li Guisen, Guo Hongpeng, Zhang Xu, Guo Xinli, Lv Simian, Zhou Hairui, Bei Lei, Wu Dongmei

Abstract excerpt

Hyperoside, a common flavonoid glycoside, was evaluated for developmental toxicity in zebrafish embryos (6-96 hpf). Hyperoside reduced hatchability and survival (96-h LC50 170.9 μM; LC10 118.3 μM) and caused prominent cardiac defects, including tachycardia, pericardial edema, and atrioventricular malformation, along with altered expression of cardiac markers (nppa, vmhc, sox9b, and gata4). Transcriptomic and...

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PMID: 42162927
DOI: 10.1016/j.taap.2026.117882

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