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In vivo and molecular docking studies of the pathological mechanism underlying adriamycin cardiotoxicity

28 Mar 2023

Abstract excerpt

Adriamycin (ADR), one of the most effective broad-spectrum antitumor chemotherapeutic agents in clinical practice, is used to treat solid tumors as well as hematological malignancies in adults and children. However, long-term ADR use causes several adverse reactions, including time- and dose-dependent cardiotoxicity, which limit its clinical application. In addition, the mechanism by which ADR induces...

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PMID: 36989556
DOI: 10.1016/j.ecoenv.2023.114778

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