Article

Assessing the contribution of rare-to-common protein-coding variants to circulating metabolic biomarker levels via 412,394 UK Biobank exome sequences

2021-12-27

Abstract excerpt

Genome-wide association studies have established the contribution of common and low frequency variants to metabolic biomarkers in the UK Biobank (UKB); however, the role of rare variants remains to be assessed systematically. We evaluated rare coding variants for 198 metabolic biomarkers, including metabolites assayed by Nightingale Health, using exome sequencing in participants from four genetically diverse ances...

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Literature Corpus work: 9f5bc439-1c27-593b-8a5f-c7bd1fff628b
DOI: 10.1101/2021.12.24.21268381

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