External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes.

doi:10.1097/CCM.0000000000007135

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External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes.

Critical care medicine - 1 Jul 2026

Stanski Natalja L, Zhang Bin, Ouyang Jiarong, Standage Stephen W, Cvijanovich Natalie Z, Fitzgerald Julie C, Bigham Michael T, Jain Parag N, Lutfi Riad, Allen Geoffrey L, Thomas Neal J, Baines Torrey, Haileselassie Bereketeab, Weiss Scott L, Lautz Andrew J, Kaplan Jennifer M, Zingarelli Basilia, Atreya Mihir R, Sanchez-Pinto L Nelson, Goldstein Stuart L, Liu Kathleen D

Abstract excerpt

OBJECTIVE: Sepsis-associated acute kidney injury (SAKI) is a heterogeneous condition that lacks disease-modifying treatments, and precision medicine approaches are needed. We previously derived two reproducible pediatric SAKI subphenotypes (pSAKI-1 and pSAKI-2) from readily available clinical data. We aimed to externally validate the prognostic relevance of these subphenotypes, evaluate their molecular...

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PMID: 42159375
DOI: 10.1097/CCM.0000000000007135
PMCID: PMC13334441

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