Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Golden rules for optimizing the diagnostic pathway of IDH-mutant tumors: bridging evidence and clinical practice in cholangiocarcinoma and adult-type diffuse gliomas.

Pathologica - 1 Apr 2026

Antonelli Manila, Barresi Valeria, Bertero Luca, Daniele Bruno, Fassan Matteo, Malapelle Umberto, Normanno Nicola, Pruneri Giancarlo, Scarpa Aldo

Abstract excerpt

Background: Mutations in the isocitrate dehydrogenase (IDH) genes are key biomarkers in intrahepatic cholangiocarcinoma (CCA) and adult-type diffuse gliomas, although real-world adoption of comprehensive molecular diagnostics remains uneven. This review aimed to integrate published evidence, clinical experience, and international guidelines to provide pragmatic recommendations that can standardize IDH testing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Duct Neoplasms
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Cholangiocarcinoma

Share to Glioma

Share to High-Throughput Nucleotide Sequencing

Share to Isocitrate Dehydrogenase

Share to Practice Guidelines as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 42157737
DOI: 10.32074/1591-951X-1812
PMCID: PMC13187866

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Golden rules for optimizing the diagnostic pathway of IDH-mutant tumors: bridging evidence and clinical practice in cholangiocarcinoma and adult-type diffuse gliomas.PMID 42157737Read ↗

Molecular profiling in cholangiocarcinoma: A practical guide to next-generation sequencing.Semantic proximity Read ↗

Practical considerations in screening for genetic alterations in cholangiocarcinoma.Semantic proximity Read ↗

Molecular Testing for Intrahepatic Cholangiocarcinoma: What, When, How?Semantic proximity Read ↗

Role of molecular genetics in the clinical management of cholangiocarcinomaSemantic proximity Read ↗

IDH testing in diagnostic neuropathology: review and practical guideline article invited by the Euro-CNS research committee.Semantic proximity Read ↗

Practical guidelines for molecular testing of cholangiocarcinoma in clinical practice: Italian experts’ position paperSemantic proximity Read ↗

The clinical use of IDH1 and IDH2 mutations in gliomasSemantic proximity Read ↗

Circulating tumor DNA-based detection of molecular residual disease in isocitrate dehydrogenase-mutant cholangiocarcinoma for biomarker-guided therapy.Semantic proximity Read ↗

Comparative Genomic Analysis of Intrahepatic Cholangiocarcinoma: Biopsy Type, Ancestry, and Testing PatternsSemantic proximity Read ↗

Diffuse Gliomas for Nonneuropathologists: The New Integrated Molecular Diagnostics.Semantic proximity Read ↗

Clinical utility of a blood based assay for the detection of IDH1.R132H-mutant gliomas.Semantic proximity Read ↗

Cost-effectiveness of IDH testing in diffuse gliomas according to the 2016 WHO classification of tumors of the central nervous system recommendations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.