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Article

Viral vs. Non-Viral Combined Hepatocellular-Cholangiocarcinoma: Distinct Genomic Landscapes and Survival Outcomes.

Journal of gastrointestinal cancer - 18 May 2026

Puttagunta Neha, Friedman Matthew, Khandakar Binny, Brown Timothy J, Grewal Udhayvir Singh, Hornstein Nicholas

Abstract excerpt

PURPOSE: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare, biologically heterogeneous primary liver cancer with conflicting reported outcomes. The prognostic impact of viral hepatitis in cHCC-CCA remains unclear. Given its established influence in hepatocellular carcinoma, we evaluated whether viral etiology is associated with distinct clinical and genomic features in cHCC-CCA. METHODS: A...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42149366
DOI: 10.1007/s12029-026-01494-y

Genes

ADAMTS8
BNC1
CLDN18
HMCN1
SLC16A1
TGFBR1
YES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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