Article
Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution.
Microbiology spectrum - 7 Jul 2026
Edelstein Gregory E, Sass Tatum N, Deo Rinki, Glover Owen T, Boucau Julie, Jaganathan Prasanna, Chew Kara W, Giganti Mark J, Hughes Michael D, Moser Carlee, Javan Arzhang Cyrus, Fletcher Courtney V, McCarthy Caitlyn, Wohl David A, Daar Eric S, Eron Joseph J, Currier Judith S, Singh Upinder, Smith Davey M, Fischer William, Barczak Amy K, Choudhary Manish C, Li Jonathan Z
Abstract excerpt
Interferon resistance has been implicated in SARS-CoV-2 escape from innate immunity, but exogenous interferon's impact on viral evolution and diversity is unknown. SNG001, an inhaled interferon-β1a treatment, was evaluated in the ACTIV-2/A5401 randomized controlled trial of therapeutics for COVID-19. We measured viral kinetics and performed whole-genome sequencing on longitudinal nasal swabs collected from...
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