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Article

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

28 Mar 2023

Abstract excerpt

The IFN system constitutes a powerful antiviral defense machinery. Consequently, effective IFN responses protect against severe COVID-19 and exogenous IFNs inhibit SARS-CoV-2 in vitro. However, emerging SARS-CoV-2 variants of concern (VOCs) may have evolved reduced IFN sensitivity. Here, we determined differences in replication and IFN susceptibility of an early SARS-CoV-2 isolate (NL-02-2020) and the Alpha,...

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PMID: 36977594
DOI: 10.26508/lsa.202201745

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