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Dysbiosis is associated with the behavioral phenotype observed in the triple-hit Wisket rat model of schizophrenia.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Mar 2025

Plesz Szonja B, Adlan Leatitia G, Büki Alexandra, Makra Nóra, Ligeti Balázs, Ágg Bence, Szabó Dóra, Zádori Zoltán S, Ferdinandy Péter, Horvath Gyongyi, Kekesi Gabriella

Abstract excerpt

Comorbidities between gastrointestinal diseases and psychiatric disorders have been widely reported, with the gut-brain axis implicated as a potential biological basis. Thus, dysbiosis may play an important role in the etiology of schizophrenia, which is barely detected. Triple-hit Wisket model rats exhibit various schizophrenia-like behavioral phenotypes. The present study aimed to compare the diversity and...

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PMID: 39880276
DOI: 10.1016/j.pnpbp.2025.111276

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