Article
An Interpretable PK-Informed Hybrid Model for Voriconazole Exposure Prediction: Roles of CYP2C19 Genotype and Inflammation.
Drug design, development and therapy - 1 Jan 2026
Zhou Yehui, Yun Yuting, Chen Shiting, Liu Xinyi, Liu Hao, Ren Jiaxin, Lu Mengmeng, Ling Jing, Yang Xuping, Zhou Zhou, Osei James Afriyie, Soheili Respina, Zou Jianjun, Hu Nan
Abstract excerpt
Purpose: Voriconazole (VCZ) exhibits nonlinear pharmacokinetics, a narrow therapeutic window, and substantial interindividual variability. Inaccurate dosing may lead to underexposure or overexposure, causing treatment failure or toxicity. Existing population pharmacokinetic (PPK)-machine learning (ML) models either lack mechanistic interpretability or inadequately characterize VCZ exposure. Therefore, we propose...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.