Article
Variability of voriconazole concentrations in patients with hematopoietic stem cell transplantation and hematological malignancies: influence of loading dose, procalcitonin, and pregnane X receptor polymorphisms.
European journal of clinical pharmacology - 1 Apr 2020
Zeng Guangting, Wang Linlin, Shi Lihong, Li Huilan, Zhu Miaomiao, Luo Jia, Zhang Zanling
Abstract excerpt
AIMS: Voriconazole (VCZ) displays highly variable pharmacokinetics affecting treatment efficacy and safety. We aimed to identify the factors affecting VCZ steady-state trough concentration (Cssmin) to provide evidence for optimizing VCZ treatment regimens. METHODS: A total of 510 Cssmin of 172 patients with hematopoietic stem cell transplantation and hematologic malignancies and their clinical characteristics and...
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