Intensive Dietary and Activity Counselling (IDAC) study: a randomised trial following infants genetically susceptible to type 1 diabetes to prevent β-cell dysfunction and islet autoimmunity - a study protocol.

Abstract excerpt

INTRODUCTION: Type 1 diabetes is a chronic autoimmune disease, preceded by the presence of islet autoantibodies, a preclinical state defined as islet autoimmunity. Several environmental exposures have been associated with the initiation of islet autoimmunity but the triggers remain largely unknown. Rapid growth and weight gain during childhood are some of the exposures that have been proposed to promote islet...

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