Association between breast cancer, pancreatic cancer, and melanoma in a CDKN2A variant common in the Hispanic population.

Abstract excerpt

Pathogenic and likely pathogenic variants (P/LP) in the CDKN2A gene are associated with melanoma-pancreatic cancer susceptibility syndrome. The lifetime risk for melanoma is estimated to be 28-76%, while the lifetime risk of pancreatic cancer is > 15%. A common CDKN2A variant in the Hispanic population, c.146 T > C, has conflicting interpretations of pathogenicity, with some laboratories calling this variant LP...

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