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CDKN2AGermline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations

23 Jul 2018

Abstract excerpt

Abstract Background: Pathogenic germline mutations in the CDKN2A tumor suppressor gene are rare and associated with highly penetrant familial melanoma and pancreatic cancer in non-Hispanic whites (NHW). To date, the prevalence and impact of CDKN2A rare coding variants (RCV) in racial minority groups remain poorly characterized. We examined the role of CDKN2A RCVs on the risk of pancreatic cancer among minority...

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PMID: 30038052
DOI: 10.1158/1055-9965.epi-17-1065

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