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Article

Drosophila ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human RYR1 mutations.

eLife - 13 May 2026

Zmojdzian Monika, Jagla Teresa, Cherik Florian, Dubinska-Magiera Magda, Migocka-Patrzałek Marta, Daczewska Malgorzata, Rendu John, Jagla Krzysztof, Sarret Catherine

Abstract excerpt

The ryanodine receptor (RYR) genes encode evolutionarily conserved calcium release channels involved in a wide range of calcium-dependent biological processes. Here, we show that the sole Drosophila RYR gene (dRyR) functions in differentiated somatic and cardiac muscle as well as in developing embryonic myotubes. In the larval body wall muscles, dRyR protein localizes at the SR membranes, and dRyR knockdown...

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Identifiers

PMID: 42126303
DOI: 10.7554/eLife.111053
PMCID: PMC13171102

Genes

RYR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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