Statistical Inference of Phenotype-Specific Molecular Mechanisms from Cell Line-Specific Gene Regulatory Networks with Application to Quizartinib Sensitivity.

Abstract excerpt

Gene regulatory networks differ substantially across individual cell lines, and population-level network inferences often fail to capture the underlying biological heterogeneity. To better capture this heterogeneity, cell line-specific gene network analysis is required. However, interpreting such high-dimensional cell line-specific networks remains a major challenge in the field of network biology. One...

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