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A systematic study of WGA strategies for enhanced STR and SNP genotyping on trace DNA.

International journal of legal medicine - 1 Sept 2026

Li Ya, Sun Weifen, Chen Man, Dong Bonan, Yan Jiangwei, Liu Xiling

Abstract excerpt

The robust analysis of trace DNA (≤ 100 pg) remains a persistent challenge in forensic genetics, primarily due to the high failure rates and stochastic effects associated with conventional STR typing at low template quantities. Although whole genome amplification (WGA) offers a potential solution, its effectiveness and influencing factors in forensic applications still require systematic evaluation. This study...

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PMID: 42118245
DOI: 10.1007/s00414-026-03833-x

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