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Article

Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies.

Applied and environmental microbiology - 17 Jun 2026

Chuang Ying-Chih, Behringer Megan G, Patton Gillian E, Bird Jordan T, Mazny Jeffrey L, Gliessman Jennifer R, Love Crystal E, Dalia Ankur B, McKinlay James B

Abstract excerpt

Cross-feeding is prevalent in microbial communities. Through time, cross-feeding is thought to enrich for loss-of-function mutations, thereby creating or reinforcing dependencies between community members. However, few studies have compared how cross-feeding affects the evolutionary trajectory of partners compared to monoculture conditions. Here, we compared mutations that were differentially enriched in...

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PMID: 42117636
DOI: 10.1128/aem.00363-26
PMCID: PMC13274399

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