Article
Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions.
The ISME journal - 1 Aug 2021
Turkarslan Serdar, Stopnisek Nejc, Thompson Anne W, Arens Christina E, Valenzuela Jacob J, Wilson James, Hunt Kristopher A, Hardwicke Jessica, de Lomana Adrián López García, Lim Sujung, Seah Yee Mey, Fu Ying, Wu Liyou, Zhou Jizhong, Hillesland Kristina L, Stahl David A, Baliga Nitin S
Abstract excerpt
Early evolution of mutualism is characterized by big and predictable adaptive changes, including the specialization of interacting partners, such as through deleterious mutations in genes not required for metabolic cross-feeding. We sought to investigate whether these early mutations improve cooperativity by manifesting in synergistic epistasis between genomes of the mutually interacting species. Specifically, we...
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