Article
Identification of the potentiating mutations and synergistic epistasis that enabled the evolution of inter-species cooperation.
PloS one - 1 Jan 2017
Douglas Sarah M, Chubiz Lon M, Harcombe William R, Marx Christopher J
Abstract excerpt
Microbes often engage in cooperation through releasing biosynthetic compounds required by other species to grow. Given that production of costly biosynthetic metabolites is generally subjected to multiple layers of negative feedback, single mutations may frequently be insufficient to generate cooperative phenotypes. Synergistic epistatic interactions between multiple coordinated changes may thus often underlie...
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