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Article

Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model.

Emerging infectious diseases - 1 May 2026

Flagg Meaghan, Winski Christopher J, Brackney Bridget G, Lutterman Tessa R, Ortiz-Morales Johan A, Williamson Brandi N, de Wit Emmie

Abstract excerpt

Replication of influenza A virus in human nasal epithelium affects transmissibility and disease. We compared virus replication and immune responses in human nasal epithelium infected with seasonal and highly pathogenic avian influenza A(H5N1) viruses. Contemporary H5N1 viruses replicated better than the historical isolate; however, interferon response to B3.13 genotype viruses was dampened.

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Identifiers

PMID: 42116615
DOI: 10.3201/eid3205.260053
PMCID: PMC13175096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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