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Article

Detection of Homologous Recombination Repair Gene Mutations by Tumor Tissue and Circulating Tumor DNA Testing in Prostate Cancer in the Phase III PROpel Trial.

JCO precision oncology - 1 May 2026

Armstrong Andrew J, Saad Fred, Oya Mototsugu, Shore Neal, Procopio Giuseppe, Arslan Cagatay, Mehra Niven, Brown Emma, Joung Jae Young, Sugimoto Mikio, Özgüroğlu Mustafa, Gedye Craig, Sartor Oliver, Poehlein Christian, Qiu Ping, Liu Yu-Zhen, Li Xiaodun, Harrington Elizabeth A, McGuinness David, Kang Jinyu, Barnicle Alan, Clarke Noel

Abstract excerpt

PURPOSE: In the PROpel study (ClinicalTrials.gov identifier: NCT03732820), olaparib plus abiraterone demonstrated statistically significant radiographic progression-free survival benefit versus placebo plus abiraterone in a first-line metastatic castration-resistant prostate cancer (mCRPC) population unselected by homologous recombination repair gene mutation (HRRm) status. From PROpel, we report exploratory...

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Identifiers

PMID: 42114035
DOI: 10.1200/PO-25-01109
PMCID: PMC13182812

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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