Meningococcal core and accessory phasomes vary by clonal complex.

doi:10.1099/mgen.0.000367

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Article

Meningococcal core and accessory phasomes vary by clonal complex.

Microbial genomics - 1 May 2020

Wanford Joseph J, Holmes Jonathan C, Bayliss Christopher D, Green Luke R

Abstract excerpt

Neisseria meningitidis is a Gram-negative human commensal pathogen, with extensive phenotypic plasticity afforded by phase-variable (PV) gene expression. Phase variation is a stochastic switch in gene expression from an ON to an OFF state, mediated by localized hypermutation of simple sequence repeats (SSRs). Circulating N. meningitidis clones vary in propensity to cause disease, with some clonal complexes (ccs)...

Topics

Computational Biology
Evolution, Molecular
Genome, Bacterial
Humans
Meningococcal Infections
Microsatellite Repeats
Neisseria meningitidis
Phenotype
Phylogeny
United Kingdom
Virulence Factors

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Identifiers

PMID: 32375989
DOI: 10.1099/mgen.0.000367
PMCID: PMC7371114

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