Article

Network-based population analysis of 31,595 gonococcal genomes reveals phase variability, genetic diversity and mobile element dynamics drive antimicrobial resistance and phenotypic diversity

2025-03-01

Abstract excerpt

<h4>ABSTRACT</h4> With a highly plastic genome allowing the accumulation of antimicrobial resistance (AMR) determinants, Neisseria gonorrhoeae ( Ngo ) is an urgent public health threat. To better understand the spread of AMR in Ngo and its ability to persist in humans, we performed a systematic analysis of its global population structure. From 31,595 publicly available genomes, we curated a maximally diverse r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47a55105-ff91-58ae-adfc-02c62b1db9a5
DOI: 10.1101/2025.02.28.640638

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network-based population analysis of 31,595 gonococcal genomes reveals phase variability, genetic diversity and mobile element dynamics drive antimicrobial resistance and phenotypic diversityDOI 10.1101/2025.02.28.640638Read

Neisseria gonorrhoeae Population Genomics: Use of the Gonococcal Core Genome to Improve Surveillance of Antimicrobial Resistance.Semantic proximity Read

Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance.Semantic proximity Read

Genomic epidemiology of <i>Neisseria gonorrhoeae</i> isolates from the G-ToG clinical trial, 2014-2016Semantic proximity Read

Diversity and evolution of a phase-variable multi-locus antigen in <i>Neisseria gonorrhoeae</i>Semantic proximity Read

Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria spp.Semantic proximity Read

The distribution and spread of susceptible and resistant<i>Neisseria gonorrhoeae</i>across demographic groups in a major metropolitan centerSemantic proximity Read

Using genomics to understand antimicrobial resistance and transmission in Neisseria gonorrhoeaeSemantic proximity Read

Population structure of <i>Neisseria gonorrhoeae</i> based on whole genome data and its relationship with antibiotic resistanceSemantic proximity Read

Mobile genetic elements in Neisseria gonorrhoeae: movement for changeSemantic proximity Read

Applications of genomics to slow the spread of multidrug‐resistant Neisseria gonorrhoeaeSemantic proximity Read

Longitudinal genomic analysis of Neisseria gonorrhoeae transmission dynamics in AustraliaSemantic proximity Read

[Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance].Semantic proximity Read