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Article

Mutations Targeted by Nous-209 Immunotherapy Occur Early in Lynch Syndrome Carriers' Precancer Lesions with Microsatellite Instability.

Cancer prevention research (Philadelphia, Pa.) - 1 Jun 2026

Micarelli Elisa, De Marco Lorenzo, Spaggiari Paola, D'Alise Anna Morena, Dal Buono Arianna, Menini Maddalena, Giatti Valentina, D'Aprano Alessandro, Scarselli Elisa, Hassan Cesare, Repici Alessandro

Abstract excerpt

This study provides a molecular characterization of precancerous colorectal lesions in Lynch syndrome (LS) carriers to assess the preventive potential of Nous-209 immunotherapy against colorectal cancer development. A total of 50 adenomas and 12 advanced adenomas (AA) were collected from 26 LS carriers with pathogenic variants in either MLH1 or MSH2. Molecular analyses included assessment of mismatch repair (MMR)...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42108525
DOI: 10.1158/1940-6207.CAPR-25-0388
PMCID: PMC13223544

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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