Article
RNF43 Mutations Are Associated With the Classical Molecular Subtype, Vigorous Antitumor Immune Responses, and Prolonged Survival in Pancreatic Adenocarcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2026
Wenning Anna Silvia, Bräutigam Konstantin, Aeschbacher Pauline, Acharjee Animesh, Gloor Beat, Perren Aurel, Karamitopoulou Eva
Abstract excerpt
RNF43 mutations were correlated with microsatellite status in colorectal cancer and with fewer and later recurrences in pancreatic ductal adenocarcinoma (PDAC). Here, we undertake a detailed assessment of RNF43 mutations in PDAC. A total of 313 PDACs (308 microsatellite stable [MSS] and 5 microsatellite-instable [MSI] cases) underwent next-generation sequencing (Oncomine Tumor Mutation Load assay; Thermo Fisher)....
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