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Article

Genetic analysis of primary lung interdigitating dendritic cell sarcomas.

The Journal of pathology - 1 Aug 2026

Ermakov Mikhail S, Filipe Juliana Faria, Eidenhammer Sylvia, Ott German, Halbwedl Iris, Kashofer Karl, Popper Helmut

Abstract excerpt

Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy-number alterations (CNAs) in nine IDCSs arising in the lung by whole-exome sequencing (WES) paired with shallow whole-genome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42092301
DOI: 10.1002/path.70066
PMCID: PMC13341275

Genes

ATM
BRAF
CCNE1
CDKN2A
CDKN2B
EGFR
ERBB2
MDM4
MLH1
MTAP
MYC
SMAD2
TP53
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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