Article
Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm.
Oncotarget - 15 Aug 2014
Stenzinger Albrecht, Endris Volker, Pfarr Nicole, Andrulis Mindaugas, Jöhrens Korinna, Klauschen Frederick, Siebolts Udo, Wolf Thomas, Koch Philipp-Sebastian, Schulz Miriam, Hartschuh Wolfgang, Goerdt Sergij, Lennerz Jochen K, Wickenhauser Claudia, Klapper Wolfram, Anagnostopoulos Ioannis, Weichert Wilko
Abstract excerpt
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematopoietic malignancy characterized by dismal prognosis and overall poor therapeutic response. Since the biology of BPDCN is barely understood, our study aims to shed light on the genetic make-up of these highly malignant tumors. Using targeted high-coverage massive parallel sequencing, we investigated 50 common cancer genes in 33 BPDCN samples....
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