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Article

Transcriptomic evidence of CD8⁺ T-cell exhaustion-like phenotype and mitochondrial impairment underlying immune dysregulation in feline chronic gingivostomatitis.

Scientific reports - 6 May 2026

Soltero-Rivera Maria, Wanakumjorn Patrawin, Chen Yihong, Barnum Samantha, Charpentier Luis Diego Castillo, Arzi Boaz, Arzi Natalia Vapniarsky, Kol Amir

Abstract excerpt

Feline chronic gingivostomatitis (FCGS) is a debilitating oral disease characterized by immune dysregulation and chronic inflammation. We hypothesized that CD8 + T cells from FCGS cats exhibit exhaustion features with suppressed mitochondrial pathways, and that mesenchymal stromal cell (MSC) therapy post-extractions might restore these programs. RNA sequencing was performed on peripheral CD8 + T cells from cats...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42091972
DOI: 10.1038/s41598-026-50658-0
PMCID: PMC13338055

Genes

MSC
CCR5
CD244
EOMES
GZMA
GZMB
GZMK
IL18R1
IL18RAP
KLRG1
PRDM1
RGS16
TNFSF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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