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Unveiling the Role of Endoplasmic Reticulum Stress Pathways in Canine Demodicosis.

Parasite immunology - 1 Apr 2024

Kelly Pamela A, McHugo Gillian P, Scaife Caitriona, Peters Susan, Stevenson M Lynn, McKay Jennifer S, MacHugh David E, Saez Irene Lara, Breathnach Rory

Abstract excerpt

Canine demodicosis is a prevalent skin disease caused by overpopulation of a commensal species of Demodex mite, yet its precise cause remains unknown. Research suggests that T-cell exhaustion, increased immunosuppressive cytokines, induction of regulatory T cells and increased expression of immune checkpoint inhibitors may contribute to its pathogenesis. This study aimed to gain a deeper understanding of the...

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PMID: 38607285
DOI: 10.1111/pim.13033

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TLR2

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