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Article

Subphenotypes of pneumonia defined by pulmonary histopathological features.

American journal of respiratory and critical care medicine - 1 Aug 2026

Shastry Amulya, Hiller Bradley E, Sanders Nathan L, Tseng Anna E, Kothari Jeet, O'Connell Aoife K, Gertje Hans P, Ha Catherine T, Murzin Ekaterina, Traber Katrina E, Lederer James A, Jones Matthew R, Douam Florian, Beach Thomas G, Remick Daniel G, Crossland Nicholas A, Monti Stefano, Campbell Joshua D, Mizgerd Joseph P

Abstract excerpt

RATIONALE: Establishing subphenotypes of pneumonia based on host biology will be a step toward using host-directed therapies (to complement microbe-directed therapies) more rationally and precisely. Pneumonia is a pulmonary pathophysiology, but histopathological changes within the lungs have not been leveraged for subphenotyping. OBJECTIVE: To determine whether pneumonia includes distinct subphenotypes based on...

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Identifiers

PMID: 42089675
DOI: 10.1093/ajrccm/aamag182
PMCID: PMC13424844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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