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Article

Dissecting ARL15 Function in Rheumatoid Arthritis: Insights From Ex Vivo and in Vitro Synovial Fibroblast Models.

International journal of rheumatic diseases - 1 May 2026

Kashyap Sujit, Pandey Anuj Kumar, Kumar Paritosh, Kanjilal Maumita, Kumar Uma, Thelma B K

Abstract excerpt

OBJECTIVES: ARL15, coding for a small GTPase, was identified as a non-HLA susceptibility gene in rheumatoid arthritis (RA) through a GWAS in a North Indian cohort, with serum adiponectin and ARL15 levels higher in RA patients with the associated genotype. This study aimed to delineate the functional role of ARL15 in RA pathobiology. METHODS: Differential transcriptomics in both ex vivo RA synovial fibroblasts and...

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Share to ADP-Ribosylation Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42087570
DOI: 10.1111/1756-185x.70668

Genes

ARL15
CD248
COMP
DOCK2
IFI6
IL1A
MX1
NPTX1
PTX3
TGFB2
TLR4
USP18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Dissecting ARL15 Function in Rheumatoid Arthritis: Insights From Ex Vivo and in Vitro Synovial Fibroblast Models.PMID 42087570Read ↗

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