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Article

Triple-Mutated HSV-1 Expressing Soluble B7-1 Plus CTLA-4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer.

Cancer science - 1 Jul 2026

Sugauchi Akinari, Uchihashi Toshihiro, Ito Hirotaka, Iwai Miwako, Tsurumaki Sato Yuzuri, Kurioka Kyoko, Usta Sena Zeynep, Tanaka Minoru, Kogo Mikihiko, Tanaka Susumu, Fukuhara Hiroshi, Todo Tomoki

Abstract excerpt

Cervical lymph node metastasis is a major predictor of poor prognosis in patients with oral squamous cell carcinoma (OSCC), underscoring the need for therapies that effectively target metastatic spread. We previously reported that G47Δ, a third-generation oncolytic herpes simplex virus type 1 (HSV-1), rapidly traffics from tongue tumors to cervical lymph nodes and suppresses metastasis in murine models. Based on...

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Share to B7-1 Antigen
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Herpesvirus 1, Human

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Source

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Identifiers

PMID: 42086280
DOI: 10.1111/cas.70410
PMCID: PMC13327007

Genes

MUC1
CD28
CD69

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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