Article
Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma.
Molecular cancer research : MCR - 1 Jul 2007
Uchida Daisuke, Onoue Tomitaro, Tomizuka Yoshifumi, Begum Nasima Mila, Miwa Yoshihiro, Yoshida Hideo, Sato Mitsunobu
Abstract excerpt
We have previously shown that a stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis, but not in that of distant metastasis, in oral squamous cell carcinoma (SCC). In this study, we investigated the role of the autocrine SDF-1/CXCR4 system, with a focus on distant metastasis in oral SCC cells. The immunohistochemical staining of SDF-1 and CXCR4 using...
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