Article
Replication-selective herpes simplex virus type 1 mutant therapy of cervical cancer is enhanced by low-dose radiation.
Human gene therapy - 20 Mar 2002
Blank Stephanie V, Rubin Stephen C, Coukos George, Amin Kunjlata M, Albelda Steven M, Molnar-Kimber Katherine L
Abstract excerpt
Herpes simplex virus type 1 (HSV-1)-based oncolytic treatment is a promising therapeutic approach for malignancy. Recombinant strains of HSV-1 containing mutations in the ICP 34.5 protein have been shown to replicate preferentially in rapidly proliferating malignant cells, resulting in a direct cytolytic effect. We assessed the efficacy of multimutated HSV-1 strains on human cervical cancer, and then used these...
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