Article
Predictive values of mutational variant allele frequency in overall survival and leukemic progression of myelodysplastic syndromes.
Journal of cancer research and clinical oncology - 1 Apr 2022
Jiang Lingxu, Ye Li, Ma Liya, Ren Yanling, Zhou Xinping, Mei Chen, Xu Gaixiang, Yang Haiyang, Lu Chenxi, Luo Yingwan, Zhu Shuanghong, Wang Lu, Shen Chuying, Yang Wenli, Zhang Qi, Wang Yuxia, Lang Wei, Han Yueyuan, Jin Jie, Tong Hongyan
Abstract excerpt
BACKGROUND: The implication of mutational variant allelic frequency (VAF) has been increasingly considered in the prognostic interpretation of molecular data in myeloid malignancies. However, the impact of VAF on outcomes of myelodysplastic syndromes (MDS) has not been extensively explored. METHODS: Targeted next-generation sequencing was performed in 350 newly diagnosed MDS cases. The associations of mutational...
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