Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clear Cell Chondrosarcoma With Somatic VHL Inactivation: A Case Report With Integrated Genomic and Transcriptomic Analysis.

Genes, chromosomes & cancer - 1 May 2026

Patel Lalit R, Wong Philip, Oskouei Shervin, Bahrami Armita

Abstract excerpt

BACKGROUND: Clear cell chondrosarcoma (CCC) is a rare, low-grade malignant bone tumor and a specific subtype of chondrosarcoma. In contrast to conventional central chondrosarcoma, which often exhibits recurrent IDH1/2 mutations, CCC is IDH-wildtype, and its genomic profile remains uncharacterized. Sporadic cases have been described in association with von Hippel-Lindau (VHL) disease, but somatic VHL alterations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Chondrosarcoma
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to IDH1 gene

Share to VHL gene

Share to Genomics

Share to Mutation

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 42084452
DOI: 10.1002/gcc.70130

Genes

VHL
IDH1
COL2A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clear Cell Chondrosarcoma With Somatic VHL Inactivation: A Case Report With Integrated Genomic and Transcriptomic Analysis.PMID 42084452Read ↗

Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcomaSemantic proximity Read ↗

Chondrosarcoma: biology, genetics, and epigeneticsSemantic proximity Read ↗

Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma.Semantic proximity Read ↗

Advances in the Molecular Biology of Chondrosarcoma for Drug Discovery and Precision MedicineSemantic proximity Read ↗

Targeted Next-Generation Sequencing Identifies Molecular and Genetic Events in Dedifferentiated Chondrosarcoma.Semantic proximity Read ↗

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencingSemantic proximity Read ↗

Conventional chondrosarcoma of the rib cage and sternum: clinicopathological and molecular analysis of 27 patients treated at a single institution.Semantic proximity Read ↗

Genomic Characterization of Chondrosarcoma Reveals Potential Therapeutic TargetsSemantic proximity Read ↗

VHL missense mutation delineate aggressive clear cell renal cell carcinoma subtype with favorable immunotherapeutic responseSemantic proximity Read ↗

Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Mutational analysis of primary and advanced chordoma tissue using next‐generation sequencingSemantic proximity Read ↗

IDH-negative chondrosarcoma with metachronous dedifferentiation only in the metastatic site-A diagnostic pitfall.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.