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VUStruct: A compute pipeline for high throughput and personalized structural biology.

PLoS computational biology - 1 May 2026

Moth Christopher W, Sheehan Jonathan H, Al Mamun Abdullah, Sivley R Michael, Gulsevin Alican, Rinker David C, Mchaourab Zenab F, Capra John A, Meiler Jens

Abstract excerpt

Effective diagnosis and treatment of rare genetic disorders requires the interpretation of a patient's genetic variants of unknown significance (VUSs). Today, clinical decision-making is primarily guided by gene-phenotype association databases and DNA-based scoring methods. Our web-accessible variant analysis pipeline, VUStruct, supplements these established approaches by deeply analyzing the downstream molecular...

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PMID: 42081565
DOI: 10.1371/journal.pcbi.1014183
PMCID: PMC13160433

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