Circulating PBX1 and age-related sarcopenia phenotypes: metabolic mediation analyses in a community-based study.

doi:10.1007/s41999-026-01488-w

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Article

Circulating PBX1 and age-related sarcopenia phenotypes: metabolic mediation analyses in a community-based study.

European geriatric medicine - 1 Aug 2026

Meng Xiangyuan, Zhao Zhenhu, Mao Shuhua, Yu Jianing, Liu Yuqin, Yang Xingxiang, Zhang Xin, Guo Ruihan, Yang Shuran, Liang Zhuoshuai, Wang Fengdan, Sun Lanchao, Zhao Hui, Liu Jinyu, Gao Tianlin

Abstract excerpt

PURPOSE: To determine whether circulating PBX1 is associated with AWGS2019-defined sarcopenia phenotypes in older adults, and whether alanine-related metabolites mediate the PBX1-ASMI association. METHODS: We enrolled 324 adults aged 60 years or older from Licha Town, Qingdao, China (2022-2023) and classified sarcopenia using AWGS 2019. Plasma PBX1 was quantified by ELISA, and targeted plasma metabolite profiling...

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Topics

Humans
Sarcopenia
Female
Male
Pre-B-Cell Leukemia Transcription Factor 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hand Strength

Aged

Phenotype

Middle Aged

Biomarkers

Alanine

Muscle, Skeletal

Lactic Acid

China

Walking Speed

Aging

Source

Open in PubMed

Identifiers

PMID: 42081027
DOI: 10.1007/s41999-026-01488-w

Genes

PBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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