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Article

Heterogeneous Intermediate Phenotypes of Cancer Cells with Varying Ki-67-Positivity Rates, Including Histologically HCC-like and NEC-like Cells, in Liver MiNEN.

International journal of molecular sciences - 9 Apr 2026

Ohni Sumie, Nakanishi Yoko, Hirotani Yukari, Toyonaka Ryosuke, Aramaki Osamu, Okamura Yukiyasu, Masuda Shinobu, Makishima Makoto, Esumi Mariko

Abstract excerpt

Mixed hepatocellular carcinoma (HCC)-neuroendocrine carcinoma (NEC) is a major type of liver mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). Primary liver NEC, which is very rare, is mostly associated with HCC rather than pure NEC. To characterize the cancer cell heterogeneity of the HCC and NEC components, we comprehensively analyzed the protein expression of three cancer cell biological markers (TERT,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42074034
DOI: 10.3390/ijms27083390
PMCID: PMC13116802

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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