Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?

doi:10.1007/s00535-014-0987-2

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Article

Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?

Journal of gastroenterology - 1 May 2015

Hijioka Susumu, Hosoda Waki, Mizuno Nobumasa, Hara Kazuo, Imaoka Hiroshi, Bhatia Vikram, Mekky Mohamed A, Tajika Masahiro, Tanaka Tsutomu, Ishihara Makoto, Yogi Tatsuji, Tsutumi Hideharu, Fujiyoshi Toshihisa, Sato Takamitsu, Hieda Nobuhiro, Yoshida Tsukasa, Okuno Nozomi, Shimizu Yasuhiro, Yatabe Yasushi, Niwa Yasumasa, Yamao Kenji

Abstract excerpt

BACKGROUND: The WHO classified pancreatic neuroendocrine neoplasms in 2010 as G1, G2, and neuroendocrine carcinoma (NEC), according to the Ki67 labeling index (LI). However, the clinical behavior of NEC is still not fully studied. We aimed to clarify the clinicopathological and molecular characteristics of NECs. METHODS: We retrospectively evaluated the clinicopathological characteristics, KRAS mutation status,...

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PMID: 25142799
DOI: 10.1007/s00535-014-0987-2
PMCID: PMC4653242

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KRAS

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