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Article

Obese-Inflammatory Phenotypes in Heart Failure With Preserved Ejection Fraction.

Circulation. Heart failure - 1 Aug 2020

Sabbah Michael S, Fayyaz Ahmed U, de Denus Simon, Felker G Michael, Borlaug Barry A, Dasari Surendra, Carter Rickey E, Redfield Margaret M

Abstract excerpt

BACKGROUND: Comorbidity-driven microvascular inflammation is posited as a unifying pathophysiologic mechanism for heart failure with preserved ejection fraction (HFpEF). Obesity is proinflammatory and common in HFpEF. We hypothesized that unique obesity-inflammation HFpEF phenotypes exist and are associated with differences in clinical features, fibrosis biomarkers, and functional performance. METHODS: Patients...

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Identifiers

PMID: 32809874
DOI: 10.1161/CIRCHEARTFAILURE.119.006414
PMCID: PMC7439286

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