Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real-World Cohort.

Cancer medicine - 1 May 2026

Song Jiwei, Han Tiantian, Chen Siqi, Chen Dongsheng, Liu Ziying

Abstract excerpt

BACKGROUND: Medulloblastoma (MB) is a heterogeneous pediatric brain tumor characterized by distinct molecular subtypes. Although genomics and transcriptomics have improved subtype classification and informed targeted therapies, the clinical utility of integrated molecular profiling in real-world settings remains incompletely defined. METHODS: We conducted a retrospective analysis of 131 patients with MB from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cerebellar Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genomics

Share to Germ-Line Mutation

Share to Infant

Share to Medulloblastoma

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 42056683
DOI: 10.1002/cam4.71783
PMCID: PMC13128342

Genes

MB
CDKN2A
FANCC
FANCL
NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real-World Cohort.PMID 42056683Read ↗

Medulloblastoma genomics in the modern molecular eraSemantic proximity Read ↗

Genetic screening algorithm for children with medulloblastoma: a scoring system for stratifying the risk of hereditary variantsSemantic proximity Read ↗

Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup-specific prognostic stratification using economical/accessible diagnostic methods.Semantic proximity Read ↗

Childhood Medulloblastoma: Current Therapies, Emerging Molecular Landscape and Newer Therapeutic InsightsSemantic proximity Read ↗

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.Semantic proximity Read ↗

Molecular variants and mutations in medulloblastomaSemantic proximity Read ↗

Medulloblastoma: Molecular Classification-Based Personal Therapeutics.Semantic proximity Read ↗

Integrative omics data analysis uncovers biomarker genes and potential candidate drugs for G3 medulloblastomaSemantic proximity Read ↗

Development and clinical validation of molecular subgrouping in medulloblastoma by targeted methylation sequencingSemantic proximity Read ↗

The whole-genome landscape of medulloblastoma subtypes.Semantic proximity Read ↗

Tailoring Medulloblastoma Treatment Through Genomics: Making a Change, One Subgroup at a TimeSemantic proximity Read ↗

Subgroup-Specific Diagnostic, Prognostic, and Predictive Markers Influencing Pediatric Medulloblastoma TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.