Article

Genetic screening algorithm for children with medulloblastoma: a scoring system for stratifying the risk of hereditary variants

2026-08-12

Abstract excerpt

Introduction . Medulloblastoma is the most common malignant central nervous system tumor in children, representing a molecularly heterogeneous group of neoplasms (SHH, WNT, Group 3, Group 4 subtypes). Germline mutations in predisposition genes (PTCH1, SUFU, TP53, APC, BRCA2, PALB2, ELP1, GPR161) are identified in 5–15 % of patients, predominantly in SHH and WNT subtypes. The purpose of the study – to develop a scr...

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Literature Corpus work: 9e367924-1656-59c4-a6fd-cfb96a11e9cb
DOI: 10.21682/2311-1267-2026-13-2-31-40

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