Article
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Nature communications - 24 May 2017
Sapkota Yadav, Steinthorsdottir Valgerdur, Morris Andrew P, Fassbender Amelie, Rahmioglu Nilufer, De Vivo Immaculata, Buring Julie E, Zhang Futao, Edwards Todd L, Jones Sarah, O Dorien, Peterse Daniëlle, Rexrode Kathryn M, Ridker Paul M, Schork Andrew J, MacGregor Stuart, Martin Nicholas G, Becker Christian M, Adachi Sosuke, Yoshihara Kosuke, Enomoto Takayuki, Takahashi Atsushi, Kamatani Yoichiro, Matsuda Koichi, Kubo Michiaki, Thorleifsson Gudmar, Geirsson Reynir T, Thorsteinsdottir Unnur, Wallace Leanne M, Yang Jian, Velez Edwards Digna R, Nyegaard Mette, Low Siew-Kee, Zondervan Krina T, Missmer Stacey A, D'Hooghe Thomas, Montgomery Grant W, Chasman Daniel I, Stefansson Kari, Tung Joyce Y, Nyholt Dale R
Abstract excerpt
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci...
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