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Article

Identification of a distinct cluster of LY6E+ macrophages in esophageal squamous cell carcinoma: functional phenotype, spatial interaction, and prognostic significance.

British journal of cancer - 1 Aug 2026

Chen Kun, Ni Jianjiao, Li Yida, Gu Sijia, Li Ye, Yang Xi, Goswami Shyamal, Luo Qiyu, Zhang Yalei, Qian Ling, Hu Yudi, Zhou Runye, Wang Yating, Liu Jingjing, Cai Xiuyu, Zhang Chunrong, Afridi Saifullah, Chen Yi, Wang Peng, Zhu Zhengfei

Abstract excerpt

BACKGROUND: Tumor-associated macrophages are key players in cancer progression, but their heterogeneity is not fully understood. This study aims to investigate the role of a specific macrophage subpopulation marked by LY6E in esophageal squamous cell carcinoma (ESCC). METHODS: We analyzed macrophage subsets in ESCC, focusing on LY6E+ populations. Their gene expression signature, functional characteristics, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42056379
DOI: 10.1038/s41416-026-03456-4
PMCID: PMC13372808

Genes

LY6E
ICAM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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