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Trends in breast reconstruction for BRCA1/2, PALB2 and other high penetrance germline pathogenic variant carriers undergoing risk reducing mastectomy.

Familial cancer - 28 Apr 2026

Melanson Amel, Alsuhaibani Marya, Viezel-Mathieu Alex, Dionisopoulos Tassos, Basik Mark, Boileau Jean Francois, Martel Karyne, Prakash Ipshita, Meterissian Sarkis, Vorstenbosch Joshua, Foulkes William D, Wong Stephanie M

Abstract excerpt

BACKGROUND: Women with germline pathogenic variants (GPV) in BRCA1/2, PALB2, or other high penetrance genes may consider risk reducing mastectomy (RRM) with or without reconstruction to reduce their risk of developing breast cancer. Few studies have characterized reconstructive trends in this patient population. METHODS: We conducted a retrospective cohort study of female patients with a confirmed GPV in a high...

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Identifiers

PMID: 42047902
DOI: 10.1007/s10689-026-00564-1

Genes

BRCA1
PALB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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