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Article

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off-the-shelf targeted NGS panel.

Molecular oncology - 1 Sept 2026

Casas-Arozamena Carlos, Lande Karin Teien, Diaz Eva, Vilar Ana, Cueva Juan, Arias Efigenia, Sampayo Victoria, Abalo Alicia, González Nerea, Colás Eva, Gil-Moreno Antonio, Abal Miguel, Moreno-Bueno Gema, Sørlie Therese, Lindemann Kristina, Muinelo-Romay Laura

Abstract excerpt

Intratumor heterogeneity presents a major challenge in precision oncology for endometrial cancer (EC). Circulating tumor DNA (ctDNA) offers a minimally invasive method to monitor tumor evolution and therapeutic resistance. In this retrospective study, we evaluated a tumor-agnostic NGS panel to detect and track ctDNA in 18 EC patients and directly compared its performance with a tumor-informed ddPCR approach....

Read the complete abstract on PubMed

Topics

Humans
Female
Endometrial Neoplasms
Circulating Tumor DNA
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Aged

Mutation

Retrospective Studies

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 42047179
DOI: 10.1002/1878-0261.70246
PMCID: PMC13398896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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